Hydrochloric Acid → HCID 53857755, compound

Participants

Reaction Steps

To a suspension of 1,2,3,4-tetrahydro-7-methoxycyclopent[b]indole-2-carboxylic acid (10 g, 0.043 mole) in 100 ml of absolute ethanol, was added 3 ml of ethereal HCl solution, and the mixture was stirred at ambient temperature for twenty hours. The mixture was concentrated to a brown oil (10 g), which was eluted on a silica gel column with 1% ethyl acetate/dichloromethane via HPLC. The desired fractions were combined and concentrated to afford a brown oil, which solidified on cooling to give 8.0 g of a lavender solid ,mp 82°-3° C.

Provenance & Evidence