Dimethylamine → HCID 18963992, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1,2,3,4-tetrahydro-7-methoxy-4-methylcyclopent[b]indole-2-carboxylic acid ethyl ester (6.2 g, 0.023 mole) in 25 ml of ethanol, was added dimethylamine (40% aqueous solution, 10 ml, 0.09 mole). After stirring at 100° C. in a sealed tube for four days, the solution was concentrated to a brown oil (~6 g), which was eluted on a silica gel column with 20% methanol/ethyl acetate via HPLC. The desired fraction was concentrated to a tan solid, 5.0 g, m.p. 162°-164° C.

Provenance & Evidence