Ammonia → HCID 53881535, compound

HRID 2226924Notes

Reaction equation

HRID 2226924 reaction equation
[C:1]1([CH2:7][O:8][C:9]2[CH:17]=[CH:16][C:15]3[N:14]([CH3:18])[C:13]4[CH2:19][CH:20]([C:22]([OH:24])=O)[CH2:21][C:12]=4[C:11]=3[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:25]>C(O)C>[C:1]1([CH2:7][O:8][C:9]2[CH:17]=[CH:16][C:15]3[N:14]([CH3:18])[C:13]4[CH2:19][CH:20]([C:22]([NH2:25])=[O:24])[CH2:21][C:12]=4[C:11]=3[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18964003HCID 18964003, compound

Product 1

HCID 53881535HCID 53881535, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

In a sealed tube was added a solution of 1,2,3,4-tetrahydro-7-phenylmethoxy-4-methylcyclopent[b]indole-2-carboxylic acid ecid ethyl ester (5.0 g, 0.014 mole) in 25 ml of absolute ethanol, followed by ammonia (30% aqueous solution, 10ml, 0.17 mole). After heating at 100° C. for five days, the mixture was cooled and the resultant tan precipitate collected and dried to give 3.0 g, m.p. 145°-148° C.

Workup

  1. temperaturethe mixture was cooled
  2. customthe resultant tan precipitate collected
  3. customdried
  4. customto give 3.0 g, m.p. 145°-148° C.

Sources & evidence

ORD record
ord-0facbd66cb9a4fa7b97227148a70c0d1
Source dataset
uspto-grants-1994_09
Patent number
US05350762

Reaction notes

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