Ethylamine → HCID 54335949, compound

Participants

Reaction Conditions

Reaction Steps

In a 50 ml sealed tube was dissolved 1,2,3,4-tetrahydro-4-methyl-7-methoxycyclopent[b]indole-2-carboxylic acid ethyl ester (2.8 g, 0.01 mole)in 25 ml of ethanol. To this was added an aqueous solution of ethylamine (70% solution, 5 ml, 0.075 mole). After stirring at 90° C. for five days, the mixture was concentrated to a brown solid, (~3 g) which was eluted on a silica gel column with ethyl acetate/dichloromethane (1:2) via HPLC. The desired fractions were combined to yield 1.3 g of a white solid, m.p. 162°-3° C. A sample of this material (0.5 g) was recrystallized from ethyl acetate/ether (1:10) to give the product as white crystals, 0.4 g, m.p. 163°-4° C.

Provenance & Evidence