Trichloroisocyanuric Acid → HCID 18963857, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.18 g (7.2 mmol) of 2-methylthieno[3.2-d]thiazole (from Step 1) in 35 ml of CH2Cl2 was added 670 mg (2.9 mmol) of trichloroisocyanuric acid at 0° C. The reaction was stirred at 0° C. for 30 min., then at r.t. for 2 h.; 60 mg (0.26 mmol) of trichloroisocyanuric acid was again added, and the reaction was stirred at r.t. for another hour. The product was partitioned between CH2Cl2 and aqueous NaHCO3. Chromatographic purification on silica gel using hexane/EtOAc=5:1 afforded 1.2 g (90%) of the title product. 1H NMR (CDCl3) 7.28(s, 1H), 2.82(s, 3H).

Provenance & Evidence