N-bromobutanimide → HCID 18963856, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 310 mg(1.62 mmol) of 6-chloro-2-methylthieno[3,2-d]thiazole (from Step 2) and 10 mg of benzoyl peroxide in 15 ml of CC14 was added 306 mg(1.72 mmol) of NBS at r.t. The mixture was stirred at 75° C. under radiation from a sunlamp for 30 min. The solid was filtered, the solution was evaporated to dryness and the residue purified on silica gel with hexane/EtOAc=8:1 to give 300 mg (69%) of the title product. 1H NMR (CDCl3) 7.35(s, 1H), 4.80(s,2H).

Provenance & Evidence