HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrimidine, 5-bromo-2-methoxy- → 3-Cyclobutyl-7-{[2-(methyloxy)-5-pyrimidinyl]oxy)-2,3,4,5-tetrahydro-1H-3-benzazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrimidine, 5-bromo-2-methoxy- | HCID 139657 | — |
| Reactant | 3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-OL | HCID 10082081 | — |
| Product | 3-Cyclobutyl-7-{[2-(methyloxy)-5-pyrimidinyl]oxy)-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 10064901 | — |
Reaction Steps
Example 144 (E144) was prepared from 3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (E3) and 5-bromo-2-(methyloxy)pyrimidine (PCT Int. Appl. PCT (2002), WO 02/62423) using the method described for Example 140 (E140); MS (ES+) m/e 326 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207331B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-962adb21d1c34724819e68e9e1181c5f |
| Source note | uspto-grants-2012_06 |