HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2227024Generated: November 3, 2026
Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid
https://huagongshe.com/reaction/2227024
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Veratraldehyde | HCID 8419 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(3,4-Dimethoxyphenyl)propionic acid | HCID 75019 | — |
Reaction Steps
After adding 6.25 ml of the mixture of formic acid and triethylamine prepared as described in Example 1 to 15 ml of dimethylformamide, 3.60 g (0.025 mol) of Meldrum's acid and 4.15 g (0.025 mol) of veratraldehyde were added to the above mixture, which was then heated to 110° C. during 1 hour and reacted at the same temperature for 3 hours. The product was separated from the reaction mixture by the method as described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05350872 |
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| Source dataset | uspto-grants-1994_09 |
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| ORD ID | ord-7bab4d04591e439288e6aca5910c30cd |
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| Source note | uspto-grants-1994_09 |
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