1-Bromopentane → 3-Methylene-1-octene

Temperature

0 °C

To a flask containing cuprous bromide (1.0 g) is added bromopentane (23 g) and tetrahydrofaran (154 mL). The solution is cooled to 0° C., and the Grignard reagent 1B is added. The reaction is stirred overnight, gradually warming to room temperature. To the solution is then added 30 mL saturated ammonium chloride. The reaction mixture is stirred for 10 minutes, during which time the aqueous layer turns blue. The reaction mixture is then extracted with hexanes, and the combined organic layers are dried over magnesium sulfate. The solvent is carefully removed by rotary evaporation to give 17 g of a colorless, malodorous liquid.

1. temperaturegradually warming to room temperature
2. stirringThe reaction mixture is stirred for 10 minutes, during which time the aqueous layer
3. extractionThe reaction mixture is then extracted with hexanes
4. dry with materialthe combined organic layers are dried over magnesium sulfate
5. customThe solvent is carefully removed by rotary evaporation
6. customto give 17 g of a colorless, malodorous liquid

ORD record

ord-fbd2a7a223a243578116168f001101d7

Source dataset

uspto-grants-2002_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06413448B1