Diethyl (ethoxymethylene)malonate → 2-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester

Participants

Reaction Conditions

Reaction Steps

A mixture of p-anisidine (2.20 g, 17.9 mmol) and diethyl ethoxymethylenemalonate 3.6 mL, 17.9 mmol) is heated at 130° C. for 2 h. While warm, the mixture is evacuated, then cooled to give 5.18 g of diethyl (4-methoxyphenylaminomethylene)malonate as an oil.

Provenance & Evidence