反应详情

A mixture of triethylorthoacetate (3 ml) and 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-pyridinecarbohydrazide (D54) (185 mg, 0.52 mmol) was heated at reflux for 16 hours. The reaction mixture was concentrated and the resulting residue was purified by column chromatography eluting with a mixture of 0.880 ammonia:methanol:dichloromethane (0.1:5:95) to afford the title compound (E216). MS (ES+) m/e 377 [M+H]+.

1. temperaturewas heated
2. temperatureat reflux for 16 hours
3. concentrationThe reaction mixture was concentrated
4. customthe resulting residue was purified by column chromatography
5. washeluting with a mixture of 0.880 ammonia:methanol:dichloromethane (0.1:5:95)