HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → 5,6-dichloro-N-isopropyl-1H-benzo[d]imidazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Isopropyl Isothiocyanate | HCID 75263 | — |
| Reactant | 3,4-Dichlorobenzene-1,2-diamine | HCID 10845020 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5,6-dichloro-N-isopropyl-1H-benzo[d]imidazol-2-amine | HCID 22995418 | 60% |
Reaction Steps
5,6-Dichloro-1,2-phenylenediamine (0.61 g, 3.4 mmol), isopropyl isothiocyanate (0.39 g, 3.8 mmol), dicyclohexyl carbodiimide (1.06 g, 5.14 mmol) and pyridine (10 L) were used according to general procedure I. The product was recrystallized from acetonitrile to afford a tan solid (0.46 g, 60%); m.p. 218-220° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413938B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-12e3f2f617e447bbb608f1b7f31318b7 |
| Source note | uspto-grants-2002_07 |