HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate → 5,6-Difluoro-2-(isopropylamino)-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate | HCID 17220 | — |
| Reactant | Isopropyl Isothiocyanate | HCID 75263 | — |
| Reactant | 1,2-Diamino-4,5-difluorobenzene | HCID 2736755 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5,6-Difluoro-2-(isopropylamino)-1H-benzimidazole | HCID 22995424 | 53% |
Reaction Steps
4,5-Difluoro-1,2-phenylenediamine (2.87 g, 19.91 mmol), isopropyl isothiocyanate (2.19 g, 21.65 mmol), 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (11.38 g, 26.87 mmol) and pyridine (75 mL) were used according to general method I. The product was recrystallized from 1,4-dioxane to afford 2.23 g (53%) of a white solid; m.p. 188-189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413938B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-23ba9169aaac4556a5e743ff19a68f36 |
| Source note | uspto-grants-2002_07 |