1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate → HCID 18472082, compound

Participants

Reaction Steps

3,4,5-Trifluoro-1,2-phenylenediamine (6.0 g, 31.2 mmol), isopropyl isothiocyanate (3.6 g, 35.6 mmol), 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (17.0 g, 40.1 mmol) and pyridine (225 mL) were used according to general procedure I. The title compound was recrystallized from 1,4-dioxane to provide a white solid (4.07 g, 57%); m.p. 182-184° C.; 1H NMR (DMSO-d6) δ: 10.97 (br s, 1H, NH), 7.01 (m, 1H, Ar—H), 6.80 (br s, 1H, NH), 3.91 (m, 1H, CH), 1.20 (d, J=6.4 Hz, 6H, overlapping CH3).

Provenance & Evidence