Ethanol → HCID 70179491, compound

Participants

Reaction Steps

5,6,7-Trifluoro-1-(2,3-di-O-acetyl-5-deoxy-beta-D-ribofuranosyl)-N-(1-methylethyl)-1H-benzimidazol-2-amine (0.41 g, 0.99 mmol), ethanol (10 mL), sodium carbonate (0.19 g, 1.79 mmol), water (2 mL), and methanol (5 mL) were used according to general procedure III. The title compound was purified by silica gel chromatography using 10:1 dichlormethane-methanol as eluant to provide a white solid (0.16 g, 47%); m.p. 175-178° C.: 1H NMR (DMSO-d6) δ: 7.17 (m, 1H, Ar—H), 6.78 (d, J=7.4, Hz, 1H, NH), 5.69 (dd, J=6.3, 1.8 Hz, 1H, CH), 5.26 (d, J=6.5 Hz, 1H, OH), 5.21 (d, J=5.2 Hz, 1H, OH), 4.15 (m, 1H, CH), 4.07 (m, 1H, CH), 3.86-3.74 (m, 2H, overlapping CH), 1.34 (d, J=6.3 Hz, 3H, CH3), 1.23 (d, J=6.5 Hz, 6H, overlapping CH3).

Provenance & Evidence