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HRID2227203

反应详情

EQUATION

反应方程式

HRID 2227203 的结构方程式

REACTANTS

反应物

1
结构：C#Cc1nc2cc(Cl)c(Cl)cc2n1[C@@H]1O[C@H](C)[C@@H](OC(C)=O)[C@H]1OC(C)=O
HCID57007773

未命名化合物

PRODUCTS

生成物

1
结构：C=Cc1nc2cc(Cl)c(Cl)cc2n1[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O
HCID22086272

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

5,6-Dichloro-2-ethynyl-1-(2,3-di-O-acetyl-5-deoxy-beta-D-ribofuranosyl) 1H-benzimidazole (0.85 g, 0.20 mmol) was deprotected using general procedure III. Crude product was purified by silica gel chromatography using 1:10 methanol:dichloromethane to give the title compound as an off white solid (0.04 g, 0.12 mmol, 59%); MS (ES+): m/z (rel. intensity) 351 (15, M++Na);

WORKUP

后处理

  1. customCrude product was purified by silica gel chromatography