HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18403062, compound → 2-[(Benzylhydroxyphosphinyl)methyl]pentanedioic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18403062 | HCID 18403062 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[(Benzylhydroxyphosphinyl)methyl]pentanedioic acid | HCID 9926331 | 57% |
Reaction Steps
Benzyl[2,4-di(benzyloxycarbonyl)butyl]phosphinic acid (0.5 g, 1.0 mmol) in 20 mL of water containing 120 mg of 10% Pd/C was hydrogenated at 40 psi for 6 hours. Filtration through a Celite pad followed by evaporation on high vacuum gave 0.17 g (57%) of 2-[(benzylhydroxyphosphinyl)methyl]-pentanedioic acid (4 R=CH2Ph) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413948B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-9c83afe390484ddfac236a03eb3a79b2 |
| Source note | uspto-grants-2002_07 |