HCID 70133450, compound → HCID 11336137, compound

Participants

Reaction Steps

Prepare A11 from A10 in a manner analogous to the preparation of A8 from A7 to give A11 (204 mg, 64%) as a white crystalline solid, after crystallization from methanol: mp 153-155° C. TLC Rf 0.27, ethyl acetate/hexane (1:3); 1H NMR δ 5.37-5.33 (m, 1H), 3.59-3.46 (m, 1H), 3.49 (s, 0.6H, MeOH solvate), 179 (dt, 3H, J=17.2, 1.4 Hz, 21-Me), 1.02 (s, 3H, 19-Me), 0.89 (s, 3H,); 19F NMR δ −110.27 (q of q, J=17.2, 2.0 Hz); MS (CI, CH4) m/z (rel intensity) 319 (MH+, 7), 318 (15), 317 (28), 301 (100), 299 (39), 281 (8). Analysis. Calculated for C21H31OF. 0.2 MeOH: C, 78.38; H, 9.87. Found: C, 78.40; H, 9.82.

Provenance & Evidence