HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3-ethynyl- → HCID 53970138, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 2-Thiopheneboronic acid | HCID 2733960 | — |
| Reactant | HCID 22484500 | HCID 22484500 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 53970138 | HCID 53970138 | 40% |
Reaction Steps
Following the procedure described in Example 26, the title compound was prepared in 40% yield from 7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine and thiophene-2-boronic acid followed by coupling with m-aminophenyl acetylene (27 mg, 0.233 mmoles) in methanol: MP: 230-232° C.; TS-MS: 317 (MH+); anal. RP18-HPLC RT: 5.614 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413971B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-cfb11aacd06f41beac4b4d3311788cf5 |
| Source note | uspto-grants-2002_07 |