4-Chlorophenylboronic acid → HCID 18473286, compound

Participants

Reaction Steps

Following the procedure described in Example 26, 4-chloro-[5-(4-methoxy-phenyl)]-7H-pyrrolo[2,3-d] pyrimidine, the intermediate, was made in 74% yield from 7-benzenesulfonyl-4-chloro-5iodo-7H-pyrrolo[2,3-d]pyrimidine and 4-chloro benzene boronic acid: TS-MS: 260 (MH+). The title compound was synthesized by coupling the intermediate with m-aminophenyl acetylene in 33% yield: MP: 225-227° C.; TSMS: 398 (MH+); anal. RP18-HPLC RT=6.45 minutes.

Provenance & Evidence