p-Toluenesulfonic acid → HCID 86758295, compound

Participants

Reaction Steps

To a stirred solution of 3-4 (1.1 g) in acetone (50 mL) was added p-toluenesulfonic acid (470 mg) and the mixture was heated at reflux for 2 h, then cooled to ambient temperature. The reaction mixture was concentrated at reduced pressure and the residue was diluted with ethyl acetate, washed with saturated aqueous sodium hydrogen carbonate, saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The reaction mixture was filtered and concentrated at reduced pressure to give 3-5 as an oil , which was used without further purification.

Provenance & Evidence