Propionic Acid → HCID 70158897, compound

Participants

Reaction Steps

A stirred solution of 4-5 (400 mg) and propionic acid (5 mg) in triethylorthoacetate (5 mL) was heated at 130° C. for 2 hours, then cooled to ambient temperature, The mixture was diluted with ethyl acetate, washed with saturated aqueous sodium hydrogen carbonate, saturated aqueous sodium chloride, dried over magnesium sulfate, and filtered. Following evaporative removal of the solvent, the residue was purified by flash column chromatography (silica gel, 7:3 ethyl acetate/hexanes) to give 4-6 as a colorless oil.

Provenance & Evidence