Propionic Acid → HCID 70159372, compound

Participants

Reaction Steps

A stirred solution of 5-2 (300 mg) and propionic acid (5 mg) in triethylorthoacetate (6 mL) was heated at 140° C. for 3 hours, then cooled to ambient temperature. The mixture was diluted with ethyl acetate, washed with saturated aqueous sodium hydrogen carbonate, saturated aqueous sodium chloride, dried over magnesium sulfate, and filtered. Following evaporative removal of the solvent, the residue was purified by flash column chromatography (silica gel, 9:1 ethyl acetate/methanol) to give 5-3 as a tan foam.

Provenance & Evidence