Morpholine → HCID 15907529, compound

HRID 2227341Notes

Reaction equation

HRID 2227341 reaction equation
[CH2:1]([N:3]1[C:11]2[N:10]=[C:9]([CH2:12][CH3:13])[NH:8][C:7]=2[C:6](=S)[N:5]=[CH:4]1)[CH3:2].[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[CH2:1]([N:3]1[C:11]2[C:7]([N:8]=[C:9]([CH2:12][CH3:13])[N:10]=2)=[C:6]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:5]=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 10198198HCID 10198198, compound

Product 1

HCID 15907529HCID 15907529, compound

Procedure

The product of stage (ii) (52 mg) in 5 ml of morpholine was refluxed for 21 hrs. Evaporation in vacuo gave 65 mg of crude 3,8-diethyl-6-morpholino-3H-purine.

Workup

  1. customEvaporation in vacuo

Sources & evidence

ORD record
ord-15331a99bfba43b384c4f5dea25d5cca
Source dataset
uspto-grants-2002_07
Patent number
US06413975B1

Reaction notes

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