Water → HCID 18473232, compound

Participants

Reaction Steps

TFA (1 mL) was added to a solution of N-[4-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyano-3-fluorophenyl)-1-(1-methyl-1H-imidazol-5-yl)butyl]-2-methylpropane-2-sulfinamide (0.111 g, 0.219 mmol) in CH3CN ( ): H2O (20 mL) with stirring at ambient temperature. After 0.5 h aqueous saturated NaHCO3 solution was added, the CH3CN was removed in vacuo, and the residue was chromatographed on a Chiralcel AD column eluting with 90/10, hexane/EtOH to give the two diastereomers of the title compound. MS(M+1) 393.

Provenance & Evidence