Hydrochloric Acid → HCID 18473242, compound

Participants

Reaction Steps

HCl gas was bubbled into a solution of 4-(3-hydroxy-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (2.3 g, 9.5 mmol) in EtOAc (100 mL) at −20° C. with stirring for 10 min. The solution was stoppered, stirred for 1 h, purged with Ar for 15 min, then concentrated in vacuo to the title compound as a white solid. 1H NMR (d6-DMSO) δ 8.97, br s, 1H), 7.50 (t, 1H, J=8 Hz), 7.12-7.19 (m, 2H), 3.175 (d, 2H, J=5 Hz), 3.12 (t, 2H, J=5 Hz).

Provenance & Evidence