Triethylamine → HCID 18473236, compound

Participants

Reaction Steps

3-(Piperazin-1-ylsulfonyl) phenol hydrochloride (0.065 g, 0.231 mmol) was dissolved in MeOH (5 mL), neutralized with Et3N (0.032 mL, 0.231 mmol), then treated with N-[1-(4-cyano-3-fluorophenyl)-4-oxo-1-(1-methyl-1H-imidazol-5-yl)butyl]-2-methylpropane-2-sulfinamide (0.086 g, 0.220 mmol). The pH of the solution was adjusted to 5 with HOAc, then NaCNBH3 (0.021 g, 0.330 nunol) was added, and the pH was adjusted again to 5. After stirring at ambient temperature for 18 h, the reaction mixture was concentrated in vacuo, partitioned between CH2Cl2 and aqueous saturated NaHCO3 solution, the aqueous layer washed with CH2Cl2 (2×), the organic layers combined and dried (MgSO4), filtered and concentrated to give the title product. MS(M+1) 617.

Provenance & Evidence