HCID 70102315, compound → HCID 22087109, compound

Participants

Reaction Steps

At atmospheric pressure and 20° C., a solution of 1 g of (5S)-(−)-5-[4-(4-fluorobenzyl)-1-piperidinyl-methyl]-3-(4-benzyloxyphenyl)oxazolidin-2-one [obtainable by reaction of (5R)-(−)-5-(methanesulfonyloxy-methyl) -3-p-benzyloxyphenyloxazolidin-2-one with 4- (4-fluorobenzyl)piperidine hydrochloride] in 25 ml of methanol is hydrogenated over 1 g of Raney nickel. The mixture is filtered and the solvent is removed, giving (5S)-(−)-5-[4-(4-fluorobenzyl)-1-piperidinylmethyl]-3-(4-hydroxyphenyl) oxazolidin-2-one,

Provenance & Evidence