Boron tribromide → HCID 22087109, compound

Participants

Reaction Steps

A solution of 1 g of (5S)-(−)-5-[4-(4-fluorobenzyl)-1-piperidinylmethyl]-3-(4-methoxyphenyl)-oxazolidin-2-one [obtainable by reaction of (5R)-(−)-5-(methanesulfonyloxymethyl)-3-p-methoxyphenyloxazolidin-2-one with 4- (4-fluorobenzyl)piperidine hydrochloride] in 25ml of dichloromethane is mixed with equimolar amounts of boron tribromide and stirred for 1 hour. Usual work-up gives (5S)-(−)-5-[4-(4-fluorobenzyl)-1-piperidinylmethyl]-3-(4-hydroxyphenyl)-oxazolidin-2-one,

Provenance & Evidence