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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2227436Generated: October 30, 2026

Thionyl Chloride → 2-(Chloromethyl)-1-methylpiperidine

https://huagongshe.com/reaction/2227436

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant1-Methyl-2-piperidinemethanolHCID 89394—
SolventChloroformHCID 6212—
Product2-(Chloromethyl)-1-methylpiperidineHCID 12351734%

Reaction Steps

Treatment of 1-methyl-2-piperidinemethanol (12.9 g, 0.1 mol) with thionyl chloride (7.6 ml) in chloroform (40 ml), as described in example 3, gave 1-methyl-2-(chloromethyl) piperidine (5.0 g, 34%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06413987B1
Source datasetuspto-grants-2002_07
ORD IDord-0d2f73011efa40beb08c0e50edbea1c9
Source noteuspto-grants-2002_07