Ethyl Acetate → HCID 18473741, compound

Participants

Reaction Steps

N-{2-[2-(4-Cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-(4-carboxy-benzenesulphonamide) (2.0 g, 4.3 mmol) is refluxed in 10 mL thionyl chloride for 1.5 h. The mixture is diluted with 50 mL ethyl acetate, the crystalline hydrochloride of the acid chloride is filtered off and washed with ethyl acetate/diethylether. The solid is suspended in 40 mL ethanol and slowly brought to reflux temperature. Half the ethanol is distilled off, the remainder is cooled and combined with ice water and made alkaline with aqueous potassium carbonate solution with stirring. It is diluted with water, the solid is filtered off and washed with water.

Provenance & Evidence