Triethylamine → HCID 178516717, compound

Participants

Reaction Steps

0.29 g of 3-ethoxy-4-(3-trifluoromethylphenylamino)-3-cyclobuten-1,2-dione in 25 mL of acetonitrile was added 0.28 g of 4-bromo-2-(1H-tetrazol-5-yl)-phenylamine hydrochloride and 0.1 g of triethylamine. The reaction mixture was heated at reflux for 62 hours, the reaction mixture was concentrated to an oil, the oil was dissolved in ethyl alcohol (96%), to this solution was added hydrochloric acid (4M) and a solid precipitated. The product was isolated by filtration, washed with water and dried by pulling air though it on a glass filter. Yield 0.26 g (56%) mp. 150-165° C.

Provenance & Evidence