3-Methyl-2-phenylquinoline-4-carboxylic acid → 2-(3-Methyl-2-phenylquinolin-4-yl)-5-phenyl-5-propyl-2-oxazoline

HRID 2227458Notes

Reaction equation

HRID 2227458 reaction equation
[CH3:1][C:2]1[C:3]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:4][C:5]2[C:10]([C:11]=1[C:12](O)=O)=[CH:9][CH:8]=[CH:7][CH:6]=2.[NH2:21][CH2:22][C:23]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([OH:27])[CH2:24][CH2:25][CH3:26]>>[CH3:1][C:2]1[C:3]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:4][C:5]2[C:10]([C:11]=1[C:12]1[O:27][C:23]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)([CH2:24][CH2:25][CH3:26])[CH2:22][N:21]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 6737103-Methyl-2-phenylquinoline-4-carboxylic acidHCID 229923231-Amino-2-phenylpentan-2-ol

Product 1

HCID 229923212-(3-Methyl-2-phenylquinolin-4-yl)-5-phenyl-5-propyl-2-oxazoline

Procedure

Following essentially the procedure of Example 39, (3-methy-2-phenylquinolin-4-yl)carboxylic acid and 1-amino-2-phenyl-2-pentanol are converted to the titled compound.

Sources & evidence

ORD record
ord-711eae5eb0414a91b8961da794551887
Source dataset
uspto-grants-2002_07
Patent number
US06413982B1

Reaction notes

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