Water → HCID 54233451, compound

Participants

Reaction Steps

A mixture of the compound (315 mg) obtained in Example 2c, p-toluenesulfonyl chloride (190 mg) and pyridine (2 ml) was stirred at room temperature for 70 minutes. Water was added to the reaction mixture and extraction with methylene chloride was conducted. The organic layer was washed with brine, dried with anhydrous sodium sulfate and then concentrated at reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent; ethyl acetate:n-hexane=1:1) to give the titled compound (yield, 87%).

Provenance & Evidence