Pyrazole → HCID 54055756, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the compound (233 mg) obtained in Example 7c, pyrazole (53 mg), sodium carbonate (82 mg) and dimethylformamide (6 ml) was stirred at 100° C. for 2 hours. Water was added to the reaction mixture and extraction with ethyl acetate was conducted. The organic layer was washed with brine, dried with anhydrous magnesium sulfate and then concentrated at reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent; ethyl acetate:n-hexane=1:3) to give the titled compound (yield, 62%).

Provenance & Evidence