Water → HCID 70156854, compound

Participants

Reaction Steps

1.50 g of 4-[(E)-2-[N-methyl-N-(3-pyridylmethyl)carbamoyl]ethenyl]phenyl acetate was dissolved in 10 ml methanol, and then stirred with 1 ml of water and 0.36 g of potassium hydroxide at room temperature for 1.5 hours. After the reaction mixture was concentrated under reduced pressure, the residue was neutralized with diluted hydrochloric acid, extracted with ethyl acetate, washed with water, and then dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give a residue, which was then purified via column chromatography on silica gel (dichloromethane:methanol=30:1) to provide (E)-3-(4-hydroxyphenyl)-N-methyl-N-(3-pyridylmethyl)-2-propenoic acid amide (1.00 g).

Provenance & Evidence