反应详情

Next, 296 mg of p-anisyl 4-formylcinnamate and 0.14 ml of methyl bromoacetate were dissolved in 4 ml benzene, and mixed with 95 mg of zinc powder to form a suspension, followed by heating under a stream of argon for 5 hours. The reaction mixture was allowed to cool, mixed with 10% sulfuric acid, extracted with ether and then washed with 5% sulfuric acid. The organic layer was washed with 10% aqueous sodium carbonate, and dried over magnesium sulfate. The drying agent was filtered off and the filtrate was evaporated under reduced pressure and dried to give p-anisyl 4-[1-hydroxy-2-(methoxycarbonyl)ethyl]-cinnamate of interest (51 mg, 14%) as a pale yellow liquid.

1. customto form a suspension
2. temperatureby heating under a stream of argon for 5 hours
3. temperatureto cool
4. extractionextracted with ether
5. washwashed with 5% sulfuric acid
6. washThe organic layer was washed with 10% aqueous sodium carbonate
7. dry with materialdried over magnesium sulfate
8. filtrationThe drying agent was filtered off
9. customthe filtrate was evaporated under reduced pressure
10. customdried