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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2227497Generated: November 1, 2026

Trifluoroacetic acid → 4-[1-Hydroxy-2-(methoxycarbonyl)ethyl]cinnamic acid

https://huagongshe.com/reaction/2227497

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 86758304HCID 86758304—
SolventAnisoleHCID 7519—
Product4-[1-Hydroxy-2-(methoxycarbonyl)ethyl]cinnamic acidHCID 7015622691%

Reaction Steps

44 mg of p-anisyl 4-[1-hydroxy-2-(methoxycarbonyl)ethyl]cinnamate was dissolved in 0.1 ml anisole, and then treated with 0.1 ml trifluoroacetic acid on ice for 30 minutes to give 4-[1-hydroxy-2-(methoxycarbonyl)ethyl]cinnamic acid (27 mg, 91%) as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06413995B1
Source datasetuspto-grants-2002_07
ORD IDord-c365f17cf67841189b24c30ba918c4d6
Source noteuspto-grants-2002_07