HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → methyl 3-hydroxy-3-[4-[2-[N-(3-pyridylmethyl)carbamoyl]ethenyl]phenyl]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Pyridinemethanamine | HCID 31018 | — |
| Reactant | Diethyl cyanophosphonate | HCID 76257 | — |
| Reactant | 4-[1-Hydroxy-2-(methoxycarbonyl)ethyl]cinnamic acid | HCID 70156226 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | methyl 3-hydroxy-3-[4-[2-[N-(3-pyridylmethyl)carbamoyl]ethenyl]phenyl]propionate | HCID 70156661 | — |
Reaction Steps
Finally, 82 mg of 4-[1-hydroxy-2-(methoxycarbonyl)ethyl]cinnamic acid was dissolved in 37 μl 3-(aminomethyl)pyridine and 1 ml dimethylformamide, and then treated with 55 μl diethyl cyanophosphate and 50 μl triethylamine on ice for 1 hour to give methyl 3-hydroxy-3-[4-[2-[N-(3-pyridylmethyl)carbamoyl]ethenyl]phenyl]propionate of interest (17 mg, 15%) as an amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413995B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-2013fe07e8eb47299b2118af8c06cf37 |
| Source note | uspto-grants-2002_07 |