Sodium Hydroxide → HCID 73864397, compound

Participants

Reaction Steps

A solution of ethyl [4-[2-cyano-2-[N-(3-pyridylmethyl)carbamoyl]ethenyl]phenoxy]acetate (730 mg) in 30 ml methanol was stirred with 10 ml of 0.2 mol/l aqueous sodium hydroxide at room temperature for 18 hours. After evaporation of methanol, the reaction mixture was mixed with 100 ml water and then extracted with 30 ml ethyl acetate to remove unreacted components. The aqueous layer was concentrated until a solid came out. A part of the resulting solid was filtered, and then dried over diphosphorus pentaoxide by heating under reduced pressure to give the compound of interest (156 mg, 22%) as a pale yellow solid.

Provenance & Evidence