Hydrochloric Acid → HCID 18473818, compound

Participants

Reaction Steps

1.94 g of (E)-3-[4-(methoxymethoxy)phenyl]-N-(3-pyridylmethyl)-2-buteneamide was dissolved in 38 ml methanol and stirred with 1.9 ml of concentrated hydrochloric acid at room temperature for 8 hours. The reaction mixture was extracted with ethyl acetate and water, and the aqueous layer was further extracted with ethyl acetate. The combined ethyl acetate layers were washed with water and brine, and dried over anhydrous magnesium sulfate. The drying agent was filtered off and the solvent was evaporated to give a residue, which was then recrystallized from ethyl acetate/n-hexane to provide (E)-3-(4-hydroxyphenyl)-N-(3-pyridylmethyl)-2-buteneamide (1.16 g, 96.5% after 2 steps).

Provenance & Evidence