Hydrochloric Acid → HCID 12043845, compound

Participants

Reaction Steps

0.5 g of ethyl [4-[(E)-1-methyl-2-[N-(3-pyridylmethyl)carbamoyl]ethenyl]-phenoxy]acetate from Example 85 was mixed with 0.39 g of anhydrous potassium carbonate and 20 ml of 50% aqueous methanol, and then refluxed for 2 hours. The reaction mixture was adjusted to pH 6 with 3 mol/l HCl while cooling on ice, and the precipitate was filtered and dried to give [4-[(E)-1-methyl-2-[N-(3-pyridylmethyl)carbamoyl]ethenyl]phenoxy]acetic acid (179.6 mg, 39%).

Provenance & Evidence