Water → HCID 18473836, compound

HRID 2227506Notes

Reaction equation

HRID 2227506 reaction equation
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[CH3:16][O:17][CH2:18]Cl.O>ClCCl.C(NC(C)C)(C)C>[CH3:16][O:17][CH2:18][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:14][CH:15]=1

Participants

6

Reactant 3

HCID 962WaterHCID 7864Chloromethyl Methyl EtherHCID 143474-Hydroxybenzophenone

Product 1

HCID 18473836HCID 18473836, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 7912DiisopropylamineSolvent

Procedure

2 g of 4-hydroxybenzophenone was dissolved in 20 ml dichloromethane and 2.12 ml diisopropylamine, and then stirred with 0.9 ml chloromethyl methyl ether at room temperature for 16 hours. Dichloromethane and water were added to the reaction mixture, which was then extracted with dichloromethane three times, washed with saturated aqueous sodium bicarbonate and brine, and then dried over anhydrous magnesium sulfate. The drying agent was filtered off and the solvent was evaporated to give 4-(methoxymethoxy)benzophenone as an oil quantitatively. Yield: 2.44 g.

Workup

  1. extractionwas then extracted with dichloromethane three times
  2. washwashed with saturated aqueous sodium bicarbonate and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationThe drying agent was filtered off
  5. customthe solvent was evaporated

Sources & evidence

ORD record
ord-a3e37b8760854e07a74563cb1fc20e9a
Source dataset
uspto-grants-2002_07
Patent number
US06413995B1

Reaction notes

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