Hydrochloric Acid → HCID 70155280, compound

Participants

Reaction Steps

100 mg of ethyl [4-[1-phenyl-2-[N-(3-pyridylmethyl)carbamoyl]ethenyl]phenoxy]acetate was mixed with 66 mg of potassium carbonate and 10 ml of 50% aqueous methanol, and then refluxed for 2 hours. The reaction mixture was adjusted to pH 6 with 3 mol/l hydrochloric acid, extracted with ethyl acetate, washed twice with water and once with brine, followed by drying over anhydrous magnesium sulfate. The drying agent was filtered off and the solvent was evaporated to give crude crystals (100 mg), which were then recrystallized from ethyl acetate to provide [4-[1-phenyl-2-[-(3-pyridylmethyl)carbamoyl]ethenyl]phenoxy]acetic acid (80 mg, yield: 86.7%) as a white solid.

Provenance & Evidence