Hydrochloric Acid → 4-(Trifluoroacetylamino)cinnamic acid

HRID 2227511Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2227511
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[F:13][C:14]([F:21])([F:20])[C:15](OCC)=[O:16].C(N(CC)CC)C.Cl>CO>[F:13][C:14]([F:21])([F:20])[C:15]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:11][CH:12]=1)=[O:16]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 9794Ethyl trifluoroacetateHCID 929283-(4-Aminophenyl)prop-2-enoic acid

Produkt 1

HCID 734475294-(Trifluoroacetylamino)cinnamic acidAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 4-aminocinnamic acid (1.88 g), ethyl trifluoroacetate (6.8 ml) and triethylamine (4.8 ml) in 20 ml methanol was stirred at room temperature for 4 hours, and 0.3 mol/l hydrochloric acid was added thereto, on ice, to precipitate a solid, which was then filtered, washed with water, and then dried by heating under reduced pressure to give 4-(trifluoroacetylamino)cinnamic acid (2.81 g, 94%).

Aufarbeitung

  1. customon ice, to precipitate a solid, which
  2. filtrationwas then filtered
  3. washwashed with water
  4. customdried
  5. temperatureby heating under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e04b05d24db748f5a0d9ab6e6c08d7d5
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06413995B1

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