反应详情

A solution of 4-aminocinnamic acid (1.88 g), ethyl trifluoroacetate (6.8 ml) and triethylamine (4.8 ml) in 20 ml methanol was stirred at room temperature for 4 hours, and 0.3 mol/l hydrochloric acid was added thereto, on ice, to precipitate a solid, which was then filtered, washed with water, and then dried by heating under reduced pressure to give 4-(trifluoroacetylamino)cinnamic acid (2.81 g, 94%).

1. customon ice, to precipitate a solid, which
2. filtrationwas then filtered
3. washwashed with water
4. customdried
5. temperatureby heating under reduced pressure