HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2227523Generated: November 3, 2026
Methylamine → 5-[(5-chloro-1H-indol-3-yl)methyl]-2-(methylamino)-1,3-oxazol-4-one
https://huagongshe.com/reaction/2227523
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | (5-Chloroindol-3-yl)methyl-2-dimethylamino-2-oxazolin-4-one | HCID 70155188 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-[(5-chloro-1H-indol-3-yl)methyl]-2-(methylamino)-1,3-oxazol-4-one | HCID 178482437 | 63% |
Reaction Steps
To [(5-chloroindol-3-yl)methyl]-2-dimethylamino-2-oxazolin-4-one (200 mg) was added methylamine (20 ml). The mixture was refluxed at −6° C. for 1 hour. Removal of methylamine gave a residue, to which was added ether. The titled compound (120 mg) was obtained as a crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06414003B1 |
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| Source dataset | uspto-grants-2002_07 |
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| ORD ID | ord-5471d99c52e94dc2a09d802619bc681d |
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| Source note | uspto-grants-2002_07 |
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