Dodecanoyl chloride → Dodecanoic acid, 2-(dimethylamino)-1-methylethyl ester

Participants

Reaction Steps

The foregoing (N-substituted amino)- and (N,N-disubstituted amino)-alkanol alkanoates are readily prepared by reacting the corresponding aminoalkanol with lauroyl chloride in the presence of triethylamine. A solvent such as chloroform is optional but preferred. For example, 1-(N,N-dimethylamino)-2-propanol can be reacted with lauroyl chloride in chloroform and in the presence of triethylamine to form 1-(N,N-dimethylamino)-2-propanol dodecanoate (DAIPD).

Provenance & Evidence