1-Fluoro-2-iodobenzene → HCID 10086799, compound

HRID 222760Notes

Reaction equation

HRID 222760 reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[C:13]([OH:16])[CH:14]=[CH:15][C:8]=3[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[F:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1I>>[CH:1]1([N:5]2[CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][C:13]([O:16][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=4[F:17])=[CH:12][C:9]=3[CH2:10][CH2:11]2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 676731-Fluoro-2-iodobenzeneHCID 100820813-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-OL

Product 1

HCID 10086799HCID 10086799, compound

Procedure

Example 270 (E270) was prepared from 3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (E3) and 2-fluoro iodobenzene using the method described for Example 128; MS (ES+) m/e 312 [M+H]+.

Sources & evidence

ORD record
ord-156ceefcf51d4abbb23151b8a01827ae
Source dataset
uspto-grants-2012_06
Patent number
US08207331B2

Reaction notes

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