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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2227637Generated: October 31, 2026

Sodium Hydroxide → 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(3-hydroxycarbonylpropyl)amide Hydrochloride

https://huagongshe.com/reaction/2227637

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant1-Methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylicacid-N-phenyl-N-(3-ethoxycarbonylpropyl)-amide-dihydrochlorideHCID 18412677—
Product1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(3-hydroxycarbonylpropyl)amide HydrochlorideHCID 18412385—

Reaction Steps

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(3-ethoxycarbonylpropyl)amide dihydrochloride and sodium hydroxide solution.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06414008B1
Source datasetuspto-grants-2002_07
ORD IDord-ff4e5569478348aba14fcfdaa6ade64d
Source noteuspto-grants-2002_07