Sodium Hydroxide → HCID 18412605, compound

HRID 2227659Notes

Reaction equation

Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]([CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])[C:9]([C:11]2[CH:32]=[CH:31][C:14]3[N:15]([CH3:30])[C:16]([CH2:18][N:19]([C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:29])[NH2:28])=[CH:23][CH:22]=4)[CH3:20])=[N:17][C:13]=3[CH:12]=2)=[O:10])[CH:3]=1.[OH-].[Na+]>>[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])[C:9]([C:11]2[CH:32]=[CH:31][C:14]3[N:15]([CH3:30])[C:16]([CH2:18][N:19]([C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:28])[NH2:29])=[CH:23][CH:22]=4)[CH3:20])=[N:17][C:13]=3[CH:12]=2)=[O:10])[CH:3]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18412302HCID 18412302, compound

Product 1

HCID 18412605HCID 18412605, compound

Procedure

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution.

Sources & evidence

ORD record: ord-5bf198a9c27248c8a9cb3a8acd23ed50
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06414008B1

Reaction notes

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